Diencephalic and brainstem mechanisms in migraine.

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TitreDiencephalic and brainstem mechanisms in migraine.
Publication TypeJournal Article
Année de Publication2011
AuthorsAkerman S, Holland PR, Goadsby PJ
JournalNat Rev Neurosci
Volume12
Issue10
Pagination570-84
Date Published2011 Oct
ISSN1471-0048
Mots-clésBrain Stem, Diencephalon, Humans, Migraine Disorders, Neural Pathways
Résumé

Migraine is a common and complex brain disorder. Although it is clear that head pain is a key manifestation of the disorder for most patients, what drives the activation of neuronal pain pathways in susceptible patients is less obvious. There is growing evidence that migraine pathophysiology may, in part, include dysfunction of subcortical structures. These include diencephalic and brainstem nuclei that can modulate the perception of activation of the trigeminovascular system, which carries sensory information from the cranial vasculature to the brain. Dysfunction of these nuclei, and their connections to other key brain centres, may contribute to the cascade of events that results in other symptoms of migraine - such as light and sound sensitivity - thus providing a comprehensive explanation of the neurobiology of the disorder.

DOI10.1038/nrn3057
PubMed ID21931334